| First Author | Dombrowicz D | Year | 1998 |
| Journal | Immunity | Volume | 8 |
| Issue | 4 | Pages | 517-29 |
| PubMed ID | 9586641 | Mgi Jnum | J:47138 |
| Mgi Id | MGI:1202656 | Doi | 10.1016/s1074-7613(00)80556-7 |
| Citation | Dombrowicz D, et al. (1998) Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity 8(4):517-29 |
| abstractText | A role for the Fc receptor beta chain (FcRbeta) in the pathogenesis of allergy has been suggested by genetic studies. FcRbeta is a subunit common to the high-affinity IgE (FcepsilonRI) and low-affinity IgG (FcgammaRIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcRbeta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of FcepsilonRI- and FcgammaRIII-dependent responses in these mice provides unequivocal genetic evidence that FcRbeta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses. |
