| First Author | Dombrowicz D | Year | 2001 |
| Journal | J Exp Med | Volume | 193 |
| Issue | 1 | Pages | 25-34 |
| PubMed ID | 11136818 | Mgi Jnum | J:124427 |
| Mgi Id | MGI:3721499 | Doi | 10.1084/jem.193.1.25 |
| Citation | Dombrowicz D, et al. (2001) Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation. J Exp Med 193(1):25-34 |
| abstractText | A role for immunoglobulin E and its high affinity receptor (Fc epsilon RI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized Fc epsilon RI (hFc epsilon RI), with a cell distribution similar to that in humans, to Fc epsilon RI-deficient animals. In hFc epsilon RI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFc epsilon RI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas Fc epsilon RI-deficient animals were protected from colitis, demonstrating that Fc epsilon RI can affect the onset of intestinal inflammation. |
