| First Author | Günther B | Year | 1992 |
| Journal | Res Exp Med (Berl) | Volume | 192 |
| Issue | 2 | Pages | 123-30 |
| PubMed ID | 1529165 | Mgi Jnum | J:996 |
| Mgi Id | MGI:49528 | Doi | 10.1007/BF02576266 |
| Citation | Gunther B, et al. (1992) Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 mice. Res Exp Med (Berl) 192(2):123-30 |
| abstractText | The present study examined the influence of systemic administration of neuroactive drugs on delayed-type hypersensitivity (DTH) in C57BL/6 mice. The cholinergic agonist nicotine and the acetylcholinesterase inhibitor physostigmine decreased DTH, whereas the alpha-adrenergic agonist clonidine stimulated DTH. In contrast isoprenaline, a specific beta-adrenergic agonist suppressed DTH. It is concluded from these observations that the autonomic nervous system modulates those processes governing DTH. It seems that the alpha-adrenergic subsystem stimulates, whereas the beta-adrenergic subsystem and the parasympathicus inhibit DTH. |
