First Author | Yueh MF | Year | 1997 |
Journal | Biochim Biophys Acta | Volume | 1350 |
Issue | 3 | Pages | 267-71 |
PubMed ID | 9061021 | Mgi Jnum | J:38483 |
Mgi Id | MGI:85866 | Doi | 10.1016/s0167-4781(97)00004-3 |
Citation | Yueh MF, et al. (1997) Pulmonary flavin-containing monooxygenase (FMO) in rhesus macaque: expression of FMO2 protein, mRNA and analysis of the cDNA. Biochim Biophys Acta 1350(3):267-71 |
abstractText | Pulmonary microsomes from Rhesus macaque express a flavin-containing monooxygenase (FMO) resembling the FMO2 ortholog from rabbit with respect to immunochemical cross-reactivity and expression in lung, but not liver. A full-length cDNA was cloned following screening of a Rhesus macaque lung cDNA library. The nucleotide sequence contained an open reading frame encoding 535 amino acids with 85 and 84% identity to FMO2 from rabbit and guinea pig, respectively, and an identical location of the putative FAD- and NADP-binding sites. Northern blots of monkey lung mRNA revealed multiple size FMO2 transcripts. These mRNA transcripts are expressed in lung, but not in liver or kidney. |