| First Author | Nakagawa O | Year | 1996 |
| Journal | FEBS Lett | Volume | 392 |
| Issue | 2 | Pages | 189-93 |
| PubMed ID | 8772201 | Mgi Jnum | J:35061 |
| Mgi Id | MGI:82512 | Doi | 10.1016/0014-5793(96)00811-3 |
| Citation | Nakagawa O, et al. (1996) ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett 392(2):189-93 |
| abstractText | We recently identified a novel human protein kinase, p160 ROCK, as a putative downstream target of the small GTPase Rho. Using the human ROCK cDNA as a probe, we isolated cDNA of two distinct, highly related sequences from mouse libraries. One encoded a mouse counterpart of human ROCK (ROCK-I), and the other encoded a novel ROCK-related kinase (ROCK-II). Like ROCK/ROCK-I, ROCK-II also bound to GTP-Rho selectively. ROCK-I mRNA was ubiquitously expressed except in the brain and muscle, whereas ROCK-II mRNA was expressed abundantly in the brain, muscle, heart, lung and placenta. These results suggest that at least two ROCK isoforms are present in a single species and play distinct roles in Rho-mediated signalling pathways. |
