| First Author | Li S | Year | 2007 |
| Journal | Int J Biochem Cell Biol | Volume | 39 |
| Issue | 7-8 | Pages | 1483-8 |
| PubMed ID | 17350876 | Mgi Jnum | J:123847 |
| Mgi Id | MGI:3719757 | Doi | 10.1016/j.biocel.2007.01.027 |
| Citation | Li S (2007) Src kinase signaling in leukaemia. Int J Biochem Cell Biol 39(7-8):1483-8 |
| abstractText | Role of Src kinases in acute lymphoblastic leukaemia has been recently demonstrated in leukaemia mouse model. Retained activation of Src kinases by the BCR-ABL oncoprotein in leukaemic cells following inhibition of BCR-ABL kinase activity by imatinib indicates that Src activation by BCR-ABL is independent of BCR-ABL kinase activity and provides an explanation for reduced effectiveness of the BCR-ABL kinase activity inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukaemia. Simultaneous inhibition of kinase activity of both BCR-ABL and Src kinases results in long-term survival of mice with acute lymphoblastic leukaemia. Leukaemic stem cells exist in acute lymphoblastic leukaemia, and complete eradication of this group of cells would provide a curative therapy for this disease. |
