| First Author | Tao X | Year | 2002 |
| Journal | Neuron | Volume | 33 |
| Issue | 3 | Pages | 383-95 |
| PubMed ID | 11832226 | Mgi Jnum | J:76631 |
| Mgi Id | MGI:2179876 | Doi | 10.1016/s0896-6273(01)00561-x |
| Citation | Tao X, et al. (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33(3):383-95 |
| abstractText | Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression. |
