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Allele : Lrrk2<tm4.1Mjff> leucine-rich repeat kinase 2; targeted mutation 4.1, The Michael J Fox Foundation
Primary Identifier  MGI:5466851 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Lrrk2
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector is designed to introduce an aspartate to alanine (D1994A) substitution at codon 1994 in exon 41 of the endogeneous locus. In addition, an FRT-flanked neomycin resistance (neo) cassette was introduced 400 bp downstream of exon 41. Flp-mediated recombination removed the FRT-flanked neo cassette.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Lrrk2<D1994A>,
  • Lrrk2<D1994A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele




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