| First Author | Menz K | Year | 1996 |
| Journal | Biochim Biophys Acta | Volume | 1309 |
| Issue | 1-2 | Pages | 14-20 |
| PubMed ID | 8950169 | Mgi Jnum | J:36773 |
| Mgi Id | MGI:84196 | Doi | 10.1016/s0167-4781(96)00132-7 |
| Citation | Menz K, et al. (1996) INMP, a novel intranuclear matrix protein related to the family of intermediate filament-like proteins: molecular cloning and sequence analysis. Biochim Biophys Acta 1309(1-2):14-20 |
| abstractText | An important step in understanding nuclear structure and its function in replication and gene regulation is the cloning and characterisation of nuclear matrix proteins. A full-length cDNA-clone, encoding a novel nuclear matrix protein, was isolated from a (lambda gt11 cDNA library derived from murine macrophages. The antibody used for the screen was raised against a single polypeptide isolated from two-dimensional gel electrophoresis of nuclear matrix preparations. The cDNA encodes a protein of 446 amino acids named INMP for intranuclear matrix protein. INMP displays several salient features, a coiled-coil domain, a leucine zipper, a number of phosphorylation sites and a putative nuclear localisation signal. Sequence homology comparisons indicate that INMP is a unique protein which is evolutionary related to the gene family of intermediate filament-like proteins, especially the nuclear lamins. |
