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Publication : Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10.

First Author  Kapfhamer D Year  1995
Journal  Genomics Volume  27
Issue  1 Pages  189-91
PubMed ID  7665168 Mgi Jnum  J:25618
Mgi Id  MGI:73332 Doi  10.1006/geno.1995.1023
Citation  Kapfhamer D, et al. (1995) Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. Genomics 27(1):189-91
abstractText  The ankyrin3 gene encodes a novel form of ankyrin, AnkyrinG, expressed in multiple tissues but characteristically present at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. We have localized ANK3 to human Chromosome 10q21 by fluorescence in situ hybridization. The position of the murine homologue was determined by intersubspecific backcross analysis, mapping Ank3 to mouse Chromosome 10, between microsatellite marker D10Mit31 and the Bcr gene. This interval is known to comprise a region syntenic to human 10q. The localization of ANK3 is a preliminary step in identifying neurological disorders potentially associated with the gene.
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