| First Author | Engblom D | Year | 2003 |
| Journal | Nat Neurosci | Volume | 6 |
| Issue | 11 | Pages | 1137-8 |
| PubMed ID | 14566340 | Mgi Jnum | J:89960 |
| Mgi Id | MGI:3042060 | Doi | 10.1038/nn1137 |
| Citation | Engblom D, et al. (2003) Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci 6(11):1137-8 |
| abstractText | We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain endothelial cells. These animals showed no fever and no central prostaglandin (PG) E2 synthesis after peripheral injection of bacterial-wall lipopolysaccharide, but their pyretic capacity in response to centrally administered PGE2 was intact. Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain. |
