| First Author | Iijima T | Year | 2014 |
| Journal | J Cell Biol | Volume | 204 |
| Issue | 3 | Pages | 331-42 |
| PubMed ID | 24469635 | Mgi Jnum | J:208331 |
| Mgi Id | MGI:5562944 | Doi | 10.1083/jcb.201310136 |
| Citation | Iijima T, et al. (2014) Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1. J Cell Biol 204(3):331-42 |
| abstractText | The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type-specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo. |
