Primary Identifier | MGI:1343091 | Organism | mouse, laboratory |
Chromosome | 18 | NCBI Gene Number | 15183 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables chromatin DNA binding activity; histone deacetylase activity; and histone decrotonylase activity. Involved in several processes, including circadian regulation of gene expression; cornified envelope assembly; and establishment of skin barrier. Acts upstream of or within several processes, including negative regulation of cardiac muscle cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of mitotic cell cycle. Located in cytoplasm and nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and sensory organ. Used to study endometriosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human HDAC3 (histone deacetylase 3). PHENOTYPE: Disruption of this gene results in embryonic death at or around the time of gastrulation. Structural and functional abnormalities are also reported in mitochondria. [provided by MGI curators] |