| First Author | Mayer TC | Year | 1978 |
| Journal | Genetics | Volume | 90 |
| Issue | 1 | Pages | 125-31 |
| PubMed ID | 359407 | Mgi Jnum | J:6041 |
| Mgi Id | MGI:54518 | Doi | 10.1093/genetics/90.1.125 |
| Citation | Mayer TC, et al. (1978) Epidermis is the site of action of tabby (Ta) in the mouse. Genetics 90(1):125-31 |
| abstractText | The site of action of the sex-linked tabby (Ta) locus was analyzed by the technique of dermal-epidermal recombination grafting. Skin components from normal and tabby 14-day embryos were separated, recombined and grown 21 days in testes of histocompatible mice. Grafts of the combinations normal epidermis-normal dermis and normal epidermis-tabby dermis produced predominantly zig-zag hairs. Grafts of the combination tabby epidermis-normal dermis and tabby epidermis-tabby dermis produced hairs with a morphology similar to hairs found in tabby mice. We conclude from these results that the tabby locus acts within the epidermis, and has no effect on the dermis. |
