| First Author | Sohn JW | Year | 2011 |
| Journal | Neuron | Volume | 71 |
| Issue | 3 | Pages | 488-97 |
| PubMed ID | 21835345 | Mgi Jnum | J:174678 |
| Mgi Id | MGI:5140621 | Doi | 10.1016/j.neuron.2011.06.012 |
| Citation | Sohn JW, et al. (2011) Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels. Neuron 71(3):488-97 |
| abstractText | Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels. VIDEO ABSTRACT: |
