| First Author | Johnstone RW | Year | 2002 |
| Journal | Cell | Volume | 108 |
| Issue | 2 | Pages | 153-64 |
| PubMed ID | 11832206 | Mgi Jnum | J:76928 |
| Mgi Id | MGI:2180611 | Doi | 10.1016/s0092-8674(02)00625-6 |
| Citation | Johnstone RW, et al. (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108(2):153-64 |
| abstractText | Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy. |
