Primary Identifier | MGI:1195972 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 21750 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables double-stranded telomeric DNA binding activity and protein homodimerization activity. Involved in anterograde axonal transport; negative regulation of telomere maintenance via recombination; and telomeric loop formation. Acts upstream of or within in utero embryonic development; positive regulation of telomere maintenance; and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region and male germ cell nucleus. Part of telomere cap complex. Is expressed in brain; future brain; genitourinary system; heart; and liver. Orthologous to human TERF2 (telomeric repeat binding factor 2). PHENOTYPE: Homozygous null mice display embryonic lethality. [provided by MGI curators] |