| First Author | Fijneman RJ | Year | 1994 |
| Journal | Oncogene | Volume | 9 |
| Issue | 5 | Pages | 1417-21 |
| PubMed ID | 8152802 | Mgi Jnum | J:17850 |
| Mgi Id | MGI:65876 | Citation | Fijneman RJ, et al. (1994) Kras-2 alleles, mutations, and lung tumor susceptibility in the mouse--an evaluation. Oncogene 9(5):1417-21 |
| abstractText | Lung Tumor Susceptibility (LTS) in the mouse has been shown to be influenced by loci within the Major Histocompatibility Complex (MHC) and the Kras-2 regions. In crosses between susceptible and resistant strains, one allele of Kras-2 has been linked with a high LTS, whereas the other allele has been linked with a low LTS. Furthermore, these Kras-2 alleles affect differently the occurrence of Kras-2 mutations in lung tumors. In this study we evaluated the relationship between LTS, Kras-2 alleles and Kras-2 mutations, using Recombinant Congenic Strains with identical MHC haplotypes. The Kras-2 region indeed influences the frequency of Kras-2 mutations in N-ethyl-N-nitrosourea-induced lung tumors. These mutations are associated with larger tumors. However, Kras-2 affects LTS only marginally. Several strains with identical Kras-2 alleles and mutation frequency differ widely in LTS, while some strains with different alleles and mutation frequency do not. We conclude that a considerable part of the genetic variability in LTS is caused by LTS-loci other than Kras-2 and MHC. |
