Primary Identifier | MGI:1919399 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 72149 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of with a negative effect on G1 to G0 transition. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of intracellular protein-containing complex and serine/threonine protein kinase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Human ortholog(s) of this gene implicated in polyhydramnios, megalencephaly, and symptomatic epilepsy. Orthologous to human STRADA (STE20 related adaptor alpha). PHENOTYPE: Mice homozygous for a null allele exhibit incomplete postnatal lethality, decreased body size, domed skulls, malocclusion of incisors, hypotonia, tremors, enlarged brain ventricles, and abnormal neuron migration with ectopic neurons. [provided by MGI curators] |