| First Author | Ji DX | Year | 2021 |
| Journal | Elife | Volume | 10 |
| PubMed ID | 34151776 | Mgi Jnum | J:313901 |
| Mgi Id | MGI:6721339 | Doi | 10.7554/eLife.67290 |
| Citation | Ji DX, et al. (2021) Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Elife 10:e67290 |
| abstractText | Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that Sp140 is a gene encoded within the Sst1 locus that represses type I IFN transcription during bacterial infections. We generated Sp140(-/-) mice and found that they are susceptible to infection by Legionella pneumophila and Mycobacterium tuberculosis. Susceptibility of Sp140(-/-) mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (Ifnar(-/-)). Our results implicate Sp140 as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections. |
