First Author | Balch SG | Year | 1998 |
Journal | J Biol Chem | Volume | 273 |
Issue | 29 | Pages | 18656-64 |
PubMed ID | 9660840 | Mgi Jnum | J:48677 |
Mgi Id | MGI:1274857 | Doi | 10.1074/jbc.273.29.18656 |
Citation | Balch SG, et al. (1998) Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem 273(29):18656-64 |
abstractText | We report the cloning of a novel macrophage-restricted C- type lectin by differential display polymerase chain reaction. This molecule, named mouse macrophage C-type lectin, is a 219-amino acid, type II transmembrane protein with a single extracellular C-type lectin domain. Northern blot analysis indicates that it is expressed in cell lines and normal mouse tissues in a macrophage-restricted manner. The cDNA and genomic sequences of mouse macrophage C-type lectin indicate that it is related to the Group II animal C-type lectins. The mel gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex. |