| First Author | Xu H | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 3334 |
| PubMed ID | 32620760 | Mgi Jnum | J:292285 |
| Mgi Id | MGI:6447752 | Doi | 10.1038/s41467-020-17097-5 |
| Citation | Xu H, et al. (2020) The induction and function of the anti-inflammatory fate of TH17 cells. Nat Commun 11(1):3334 |
| abstractText | TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-beta signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes. |
