| First Author | Ronchetti S | Year | 2002 |
| Journal | Blood | Volume | 100 |
| Issue | 1 | Pages | 350-2 |
| PubMed ID | 12070049 | Mgi Jnum | J:77393 |
| Mgi Id | MGI:2181525 | Doi | 10.1182/blood-2001-12-0276 |
| Citation | Ronchetti S, et al. (2002) Role of GITR in activation response of T lymphocytes. Blood 100(1):350-2 |
| abstractText | In this study, we describe the generation and characterization of mice in which GITR gene (TNFRSF18 [tumor necrosis factor receptor superfamily 18]), a member of the TNFRSF expressed mainly on T lymphocytes, has been ablated (GITR(-/-) mice). Results indicate that GITR inactivation does not impair the normal development of the lymphoid organs but modulates T-cell activation. In fact, when GITR(-/-) T lymphocytes are activated by treatment with an anti-CD3 monoclonal antibody they proliferate more than wild-type cells. Moreover, activated GITR(-/-) T lymphocytes express higher levels of interleukin-2 receptor, produce larger amounts of interleukin-2, and are more sensitive to activation-induced cell death than controls. These results suggest that GITR is involved in the regulation of T-cell receptor/CD3-driven T-cell activation and programmed cell death. |
