Primary Identifier | MGI:2181182 | Organism | mouse, laboratory |
Chromosome | 15 | NCBI Gene Number | 170762 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to be a structural constituent of nuclear pore. Acts upstream of or within with a positive effect on miRNA processing and protein localization to nucleus. Acts upstream of or within atrial cardiac muscle cell action potential; mRNA export from nucleus; and protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human NUP155 (nucleoporin 155). PHENOTYPE: Mice homozygous for a gene trap allele die prior to E8.5. Mice homozygous for a gene trap allele exhibit atria fibrillation associated with shortened action potential duration. [provided by MGI curators] |