| First Author | Yi H | Year | 2017 |
| Journal | Arch Biochem Biophys | Volume | 620 |
| Pages | 52-58 | PubMed ID | 27242323 |
| Mgi Jnum | J:248700 | Mgi Id | MGI:6093789 |
| Doi | 10.1016/j.abb.2016.05.002 | Citation | Yi H, et al. (2017) MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP). Arch Biochem Biophys 620:52-58 |
| abstractText | Ischemic stroke is one of the leading causes of death and disability globally and has been regarded as a major public health problem. MicroRNA 182 (miR-182) plays important roles in cellular differentiation, cell growth, cell apoptosis and metastasis. However, the role of miR-182 in the cerebral ischemia injury has never been investigated. In the present study, we demonstrate a crucial role of miR-182 in down-regulating inhibitory member of the ASPP family (iASPP) expression and promoting cerebral ischemia injury. MiR-182 also promotes NO and 3-NT production, and Caspase3 expression, while reduces SOD and MnSOD activities. Furthermore, the amplified cerebral ischemia injury induced by miR-182 is aggravated by inhibition of iASPP. In conclusion, miR-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression. |
