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Publication : Chromosomal localization of the mouse titin gene and its relation to "muscular dystrophy with myositis" and nebulin genes on chromosome 2.

First Author  Müller-Seitz M Year  1993
Journal  Genomics Volume  18
Issue  3 Pages  559-61
PubMed ID  8307566 Mgi Jnum  J:16159
Mgi Id  MGI:64249 Doi  10.1016/s0888-7543(05)80356-8
Citation  Muller-Seitz M, et al. (1993) Chromosomal localization of the mouse titin gene and its relation to muscular dystrophy with myositis and nebulin genes on chromosome 2. Genomics 18(3):559-61
abstractText  In the mouse, the genes for the structural components of the myofibril titin and nebulin, Ttn and Neb, map to proximal Chr 2, as does the gene for a muscle disease, muscular dystrophy with myositis, mdm. To facilitate the evaluation of Ttn and Neb as possible candidates for mdm, we have determined their relative map positions, using a Mus spretus/Mus musculus interspecific backcross. The gene order (distances in cM) cenVim-16.9 +/- 4.7-Neb-7.6 +/- 3.0-Ttn, Acra-18.0 +/- 4.9-Pax-6-17.7 +/- 4.9-a ... has been determined. Considering the standard deviations, Neb, Ttn, and Acra could colocalize with mdm. Using Ttn and Neb probes, DNAs from mdm/mdm and mdm/+ mice were tested for restriction fragment variants in comparison to the M. musculus wildtype. No variants have been found with 11 restriction nucleases. Our data corroborate a conserved synteny comprising genes NEB, TTN, CHRNA1 on human Chr 2q.
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