| First Author | Kaluzhny Y | Year | 2002 |
| Journal | FEBS Lett | Volume | 527 |
| Issue | 1-3 | Pages | 279-83 |
| PubMed ID | 12220674 | Mgi Jnum | J:79023 |
| Mgi Id | MGI:2386833 | Doi | 10.1016/s0014-5793(02)03230-1 |
| Citation | Kaluzhny Y, et al. (2002) A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation. FEBS Lett 527(1-3):279 |
| abstractText | Megakaryocytes, the platelet precursors, are induced to differentiate in response to Mpl ligand. Here we report that stability of the megakaryocyte-specific platelet factor 4 (PF4) mRNA is substantially augmented in the presence of Mpl ligand. This stabilization requires protein synthesis, but the 3'-untranslated region of PF4 mRNA is not sufficient for granting the effect. This cytokine also significantly or mildly stabilizes Mpl receptor or GAPDH mRNAs, respectively, in contrast to a previously reported lack of effect on P2Y(1) receptor mRNA. Our study is the first to suggest that Mpl ligand-induced lineage specification is also determined by message stabilization. |
