| First Author | Edelmann SL | Year | 2011 |
| Journal | J Immunol | Volume | 186 |
| Issue | 10 | Pages | 5612-9 |
| PubMed ID | 21471449 | Mgi Jnum | J:173094 |
| Mgi Id | MGI:5009727 | Doi | 10.4049/jimmunol.1004010 |
| Citation | Edelmann SL, et al. (2011) Peripheral T cells re-enter the thymus and interfere with central tolerance induction. J Immunol 186(10):5612-9 |
| abstractText | The thymus mainly contains developing thymocytes that undergo thymic selection. In addition, some mature activated peripheral T cells can re-enter the thymus. We demonstrated in this study that adoptively transferred syngeneic Ag-specific T cells can enter the thymus of lymphopenic mice, where they delete thymic dendritic cells and medullary thymic epithelial cells in an Ag-specific fashion, without altering general thymic functions. This induced sustained thymic release of autoreactive self-Ag-specific T cells suggested that adoptively transferred activated T cells can specifically alter the endogenous T cell repertoire by erasing negative selection of their own specificities. Especially in clinical settings in which adoptively transferred T cells cause graft-versus-host disease or graft-versus-leukemia, as well as in adoptive tumor therapies, these findings might be of importance, because the endogenous T cell repertoire might be skewed to contribute to both manifestations. |
