| First Author | Huang Y | Year | 2020 |
| Journal | Biochem Biophys Res Commun | Volume | 522 |
| Issue | 1 | Pages | 74-80 |
| PubMed ID | 31740002 | Mgi Jnum | J:293497 |
| Mgi Id | MGI:6452909 | Doi | 10.1016/j.bbrc.2019.11.043 |
| Citation | Huang Y, et al. (2020) MicroRNA-25-3p regulates osteoclasts through nuclear factor I X. Biochem Biophys Res Commun 522(1):74-80 |
| abstractText | Osteoporosis is a bone metabolic disease, characterized by loss of bone density leading to fractures. Its incidence increases with age and affects patient quality of life. Although osteoclasts play a significant role in osteoporosis, their underlying regulatory mechanisms remain unclear. In this study, we found that microRNA (miR)-25-3p negatively regulates osteoclast function through nuclear factor I X (NFIX). Overexpression of NFIX promoted osteoclast proliferation and increased the expression of the osteoclast differentiation and activity markers tartrate-resistant acid phosphatase and cathepsin K. MiR-25-3p transfection inhibited NFIX expression, which in turn inhibited osteoclast proliferation. Collectively, our results suggest that miR-25-3p promotes osteoclast activity by regulating the expression of NFIX. Therefore, targeting miR-25-3p in osteoclasts could be a promising strategy for treating skeletal disorders involving reduced bone formation. |
