First Author | Zeisig BB | Year | 2008 |
Journal | Cancer Cell | Volume | 14 |
Issue | 5 | Pages | 345-7 |
PubMed ID | 18977321 | Mgi Jnum | J:140629 |
Mgi Id | MGI:3814244 | Doi | 10.1016/j.ccr.2008.10.008 |
Citation | Zeisig BB, et al. (2008) Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia. Cancer Cell 14(5):345-7 |
abstractText | The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L. |