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Publication : Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.

First Author  Zeisig BB Year  2008
Journal  Cancer Cell Volume  14
Issue  5 Pages  345-7
PubMed ID  18977321 Mgi Jnum  J:140629
Mgi Id  MGI:3814244 Doi  10.1016/j.ccr.2008.10.008
Citation  Zeisig BB, et al. (2008) Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia. Cancer Cell 14(5):345-7
abstractText  The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.
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