| First Author | Maloul A | Year | 2006 |
| Journal | Connect Tissue Res | Volume | 47 |
| Issue | 3 | Pages | 157-62 |
| PubMed ID | 16753809 | Mgi Jnum | J:135717 |
| Mgi Id | MGI:3794365 | Doi | 10.1080/03008200600719142 |
| Citation | Maloul A, et al. (2006) Geometric and material contributions to whole bone structural behavior in GDF-7-deficient mice. Connect Tissue Res 47(3):157-62 |
| abstractText | The growth/differentiation factors (GDFs) are a subfamily of bone morphogenetic proteins (BMPs) known to play a role in a variety of skeletal processes. Previous work using the brachypod mouse demonstrated that mice deficient in GDF-5 have long bones with diminished material properties and ash content compared with control littermates. Our aim was to examine the role of a related GDF family member, GDF-7 (BMP-12), in cortical bone by examining the geometric and material contributions to whole bone structural behavior in GDF-7-deficient mice. Femora from 16-week-old GDF-7 -/- animals had significantly smaller bone cross-sectional geometric parameters (e.g., -20% medial/lateral and anterior/posterior moments of inertia). Despite having smaller bone cross-sections, all structural parameters obtained from four-point bending tests were comparable to those of wild-type bones due to elevated cortical bone material properties (+18% modulus of elasticity, +28% yield strength, and +18% ultimate strength). No significant differences in ash content or collagen content were detected, however. These data suggest that GDF-7 deficiency is associated with elevated cortical bone material properties that compensate for decreased geometric properties, thereby preserving bone structural integrity. The compositional and/or microstructural bases for these altered material properties remain to be determined, however. |
