| First Author | Song J | Year | 2005 |
| Journal | Immunity | Volume | 22 |
| Issue | 5 | Pages | 621-31 |
| PubMed ID | 15894279 | Mgi Jnum | J:99091 |
| Mgi Id | MGI:3581099 | Doi | 10.1016/j.immuni.2005.03.012 |
| Citation | Song J, et al. (2005) Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 22(5):621-31 |
| abstractText | Sustained signaling from the T cell receptor (TCR) and costimulatory molecules is thought necessary for generating high numbers of effector T cells. Here, we show that Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation. Survivin is induced by OX40 independent of mitotic progression in late G1, and blocking Survivin suppresses S-phase transition and division of T cells and leads to apoptosis. Moreover, Survivin expression alone is sufficient to restore proliferation and to antagonize apoptosis in costimulation-deficient T cells and can rescue T cell expansion in vivo. Survivin allows effector T cells to accumulate in large numbers, but Bcl-2 family proteins are required for T cell survival after the phase of active division. Thus, sustained Survivin expression from costimulatory signaling maintains T cell division over time and regulates the extent of clonal expansion. |
