| First Author | Hoek KL | Year | 2010 |
| Journal | Immunity | Volume | 33 |
| Issue | 2 | Pages | 254-65 |
| PubMed ID | 20691614 | Mgi Jnum | J:163921 |
| Mgi Id | MGI:4830193 | Doi | 10.1016/j.immuni.2010.07.016 |
| Citation | Hoek KL, et al. (2010) Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity 33(2):254-65 |
| abstractText | Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-targeted mice we show that altered splenic B cell migration confers a significant in vivo gain-of-function phenotype to FO B cells, including the ability to quickly respond to MZ-associated antigens and pathogens in a T cell-dependent manner. This work demonstrates that in wild-type animals, naive FO B cells are actively removed from the MZ, thus restricting their capacity to respond to blood-borne pathogens. |
