| First Author | Tsai MJ | Year | 2014 |
| Journal | Endocrinology | Volume | 155 |
| Issue | 2 | Pages | 392-404 |
| PubMed ID | 24248465 | Mgi Jnum | J:208719 |
| Mgi Id | MGI:5564863 | Doi | 10.1210/en.2013-1663 |
| Citation | Tsai MJ, et al. (2014) TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance. Endocrinology 155(2):392-404 |
| abstractText | The perinatal period is critical for beta-cell mass establishment, which is characterized by a transient burst in proliferation to increase beta-cell mass in response to the need for glucose homeostasis throughout life. In adulthood, the ability of beta-cells to grow, proliferate, and expand their mass is also characteristic of pathological states of insulin resistance. Translationally controlled tumor-associated protein (TCTP), an evolutionarily highly conserved protein that is implicated in cell growth and proliferation, has been identified as a novel glucose-regulated survival-supporting protein in pancreatic beta-cells. In this study, the enhanced beta-cell proliferation detected both during the perinatal developmental period and in insulin-resistant states in high-fat diet-fed mice was found to parallel the expression of TCTP in pancreatic beta-cells. Specific knockout of TCTP in beta-cells led to increased expression of total and nuclear Forkhead box protein O1 and tumor suppressor protein 53, and decreased expression of p70S6 kinase phosphorylation and cyclin D2 and cyclin-dependent kinase 2. This resulted in decreased beta-cell proliferation and growth, reduced beta-cell mass, and insulin secretion. Together, these effects led to hyperglycemia. These observations suggest that TCTP is essential for beta-cell mass expansion during development and beta-cell adaptation in response to insulin resistance. |
