| First Author | Kohlhaas S | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 5 | Pages | 2578-82 |
| PubMed ID | 19234151 | Mgi Jnum | J:146268 |
| Mgi Id | MGI:3837106 | Doi | 10.4049/jimmunol.0803162 |
| Citation | Kohlhaas S, et al. (2009) Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 182(5):2578-82 |
| abstractText | Foxp3 is a transcription factor that is essential for the normal development of regulatory T cells (Tregs). In the absence of microRNAs (miRNAs), Foxp3(+) Tregs develop but fail to maintain immune homeostasis, leading to a scurfy-like disease. Global analysis of the network of genes regulated by Foxp3 has identified the miRNA miR-155, which is highly expressed in Tregs, as a direct target of Foxp3. In this study we report that miR-155-deficient mice have reduced numbers of Tregs, both in the thymus and periphery, due to impaired development. However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function. |
