Type | MGI:General | Description | bone marrow cells show a dramatic decrease in colony formation in vitro (70% reduction compared to wild-type cells) in response to LPS, a B cell mitogen; splenocytes show a 30% reduction in colony formation in response to LPS reduced colony formation (by 40%) by bone marrow cells is seen in response to Il3, Il7 and CSF1 indicating that responses of multipotential progenitors, pre-B cells and macrophages in bone marrow are altered |