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Allele : Cers4<tm1.1Kwi> ceramide synthase 4; targeted mutation 1.1, Klaus Willecke
Primary Identifier  MGI:5638668 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Cers4
Transmission  Germline Strain of Origin  129P2/OlaHsd-Hprt1<b-m3>
Is Recombinase  false Is Wild Type  false
molecularNote  A genomic region including exons 2 - 11 was replaced with an NLS-lacZ cassette and an FRT flanked neo cassette via homologous recombination. Flp mediated recombination removed the neo cassette. Ceramide synthase activity assays revealed a significant decrease in activity towards C20 acyl-CoA to ~10% in the epidermis and to ~20% in the dermis of homozygous mutant mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Cers4<->,
  • Cers4<->
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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