| Type | MGI:General | Description | tau-positive spheroidal inclusions in spinal cord neurons are visible by 1 month of age size and number increases up to 6-9 months of age, but decreases in number by 12 months of age inclusions are the size of medium to large spinal cord neurons and some appear to arise within the proximal axons of spinal cord neurons spinal cord inclusions are most frequent at the grey-white matter junction spinal cord inclusions in line 7 are smaller and less abundant than in line 43 tau-positive intraneuronal aggregates are seen in the brain, but they are smaller and appear later than in the spinal cord tau-positive inclusions appear in cortical neurons and brainstem by 6 months of age inclusions in cortical neurons occur in proximal axons or somadendritic domains of neurons inclusions are visible in pontine neurons by 1 month of age and in the cerebral cortex at 6 months of age tau deposits become increasingly insoluble with age |
