| First Author | Awgulewitsch A | Year | 1990 |
| Journal | Proc Natl Acad Sci U S A | Volume | 87 |
| Issue | 16 | Pages | 6428-32 |
| PubMed ID | 1696731 | Mgi Jnum | J:12752 |
| Mgi Id | MGI:60971 | Doi | 10.1073/pnas.87.16.6428 |
| Citation | Awgulewitsch A, et al. (1990) Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region. Proc Natl Acad Sci U S A 87(16):6428-32 |
| abstractText | The mouse Hox gene family is a set of mammalian homeobox genes that may represent developmental control genes. Complete information about the primary structure of these genes is a prerequisite for a systematic analysis of the mechanisms that determine their complex tempero-spatial expression patterns. In this report we describe the complete sequence of the Hox-3.1 locus and provide evidence for several closely spaced transcriptional start sites. Sequence analysis of the 5' region of the Hox-3.1 gene extending to its nearest upstream neighbor, Hox-3.2, allowed us to identify sequences known to be capable of interactions with transcription factors. Several of these sequence motifs are similar to cis-regulatory elements found in the regulatory regions of other known developmentally regulated genes. |
