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Publication : Technologically advanced cancer modeling in mice.

First Author  Tuveson DA Year  2002
Journal  Curr Opin Genet Dev Volume  12
Issue  1 Pages  105-10
PubMed ID  11790563 Mgi Jnum  J:73857
Mgi Id  MGI:2156960 Doi  10.1016/s0959-437x(01)00272-6
Citation  Tuveson DA, et al. (2002) Technologically advanced cancer modeling in mice. Curr Opin Genet Dev 12(1):105-10
abstractText  Multiple approaches now exist for the generation of genetically engineered murine cancer models. These new models utilize latent, conditional and inducible alleles to better mimic the in vivo setting in which sporadic human cancers occur. The murine tumor models are beginning to reveal mysteries of tumorigenesis, such as the role of the tumor microenvironment and the dependence of tumors on continuous oncogenic stimulation.
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