| First Author | Guo WX | Year | 1996 |
| Journal | FEBS Lett | Volume | 398 |
| Issue | 2-3 | Pages | 259-64 |
| PubMed ID | 8977119 | Mgi Jnum | J:37080 |
| Mgi Id | MGI:84484 | Doi | 10.1016/s0014-5793(96)01216-1 |
| Citation | Guo WX, et al. (1996) Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters. FEBS Lett 398(2-3):259-64 |
| abstractText | We have cloned and sequenced mouse utrophin cDNA, and successfully expressed full length utrophin (400 kDa) in both muscle and non-muscle cells. The expression of recombinant utrophin is compared with that of its homologue, dystrophin (427 kDa). We demonstrate that recombinant utrophin is targeted into agrin-induced acetylcholine receptor (AChR) clusters, while recombinant dystrophin is evenly distributed along cell membranes in cultured Sol 8 muscle cells. This observation suggests that utrophin and dystrophin may interact with different cytoskeletal proteins. The C-terminal domains are found to be responsible for the association of utrophin with AChR clusters. |
