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Publication : Prep2: cloning and expression of a new prep family member.

First Author  Haller K Year  2002
Journal  Dev Dyn Volume  225
Issue  3 Pages  358-64
PubMed ID  12412021 Mgi Jnum  J:80127
Mgi Id  MGI:2429830 Doi  10.1002/dvdy.10167
Citation  Haller K, et al. (2002) Prep2: cloning and expression of a new prep family member. Dev Dyn 225(3):358-64
abstractText  We describe Prep2, a new murine homeobox-containing gene closely related to Prep1. The PREP2 protein belongs to the three amino acid loop extension (TALE) superclass of homeodomain-containing proteins and encodes a polypeptide of 462 residues. As for PREP1, PREP2 binds an appropriate site on DNA as a heterodimer with PBX1A. Northern analysis, immunoblotting, immunohistochemistry, and in situ hybridization show widespread Prep2 expression during organogenesis and in the adult. The data suggest that Prep2 functions to varying degrees in a broad array of tissues and developmental processes.
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