| First Author | Motter AL | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 15 | Pages | 2257-62 |
| PubMed ID | 18503767 | Mgi Jnum | J:137026 |
| Mgi Id | MGI:3797664 | Doi | 10.1016/j.febslet.2008.05.021 |
| Citation | Motter AL, et al. (2008) TRPV1-null mice are protected from diet-induced obesity. FEBS Lett 582(15):2257-62 |
| abstractText | We explored a role for the capsaicin receptor, transient receptor potential channel vanilloid type 1 (TRPV1), in the regulation of feeding and body mass. On a 4.5% fat diet, wild-type and TRPV1-null mice gained equivalent body mass. On an 11% fat diet, however, TRPV1-null mice gained significantly less mass and adiposity; at 44 weeks the mean body weights of wild-type and TRPV1-null mice were approximately 51 and 34g, respectively. Both groups of mice consumed equivalent energy and absorbed similar amounts of lipids. TRPV1-null mice, however, exhibited a significantly greater thermogenic capacity. Interestingly, we found that 3T3-L1 preadipocytes expressed functional calcitonin gene-related peptide receptors. Thus, these data support a potential neurogenic mechanism by which TRPV1-sensitive sensory nerves may regulate energy and fat metabolism. |
