| Primary Identifier | MGI:2158925 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 234515 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit osteoporosis, reduced long bone length, increased osteoclast numbers and size, increased osteoblast numbers, and increased bone resorption and resorption. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
