| First Author | McCarty N | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 1 | Pages | 65-72 |
| PubMed ID | 15608642 | Mgi Jnum | J:94869 |
| Mgi Id | MGI:3521627 | Doi | 10.1038/ni1145 |
| Citation | McCarty N, et al. (2005) Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol 6(1):65-72 |
| abstractText | Signaling through the T cell antigen receptor leading to elimination (negative selection) or differentiation (positive selection) of developing thymocytes generates a self-tolerant T cell repertoire. Here we report that the serine-threonine kinase MINK selectively connects the T cell receptor to a signaling pathway that mediates negative but not positive selection. Analysis of this pathway suggested that the essential function of MINK in the elimination of self-reactive thymocytes may be associated with 'downstream' activation of Jun kinase and enhancement of expression of the proapoptotic molecule Bim. |
