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Allele : Tg(tetO-SNCA*A53T)33Vle transgene insertion 33, Virginia M-Y Lee
Primary Identifier  MGI:5289968 Allele Type  Transgenic
Attribute String  Humanized sequence, Inducible, Inserted expressed sequence Gene  Tg(tetO-SNCA*A53T)33Vle
Strain of Origin  (C57BL/6 x C3H)F1 Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  This transgene consists of the human alpha-synuclein cDNA encoding a mutated protein with an Ala53Thr mutation under the control of the tetracycline responsive promoter. The mutant alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression.
  • mutations:
  • Insertion
  • synonyms:
  • tetP-A53Talpha-syn,
  • tetP-A53Talpha-syn
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

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0 Driven By

4 Publication categories

Trail: Allele




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