| First Author | Lyon MF | Year | 1980 |
| Journal | Mouse News Lett | Volume | 62 |
| Pages | 49 | Mgi Jnum | J:13833 |
| Mgi Id | MGI:62012 | Citation | Lyon MF, et al. (1980) Relation of gyro and hypophosphataemia. Mouse News Lett 62:49 |
| abstractText | Full text of MNL contribution: 5. Relation of Gyro and Hypophosphataemia. Gy and Hyp both affect bone growth and are located close to each other on the X-chromosome. The question therefore arises whether they are allelic. Gy+/+Ta females have been crossed with Hyp/Y. Their Gy+/+Hyp daughters have been used for linkage tests and serum phosphate has been measured on Gy, Hyp and normal control animals from the various crosses. Both Gy/Y males and Gy/+ females have reduced serum phosphate levels. The mg/100 ml (no. mice) were Gy/Y, 4.15(50); Hyp/Y, 3.24(31); +/Y or Ta/Y, 7.37(33) and for females Gy/+, 2.91(28); +/+, 4.99(17). Both Gy/Y males and Gy/+ females have defective bone growth of rachitic type, but the females are less affected than the males. In a relatively small number of offspring no crossovers between Gy and Hyp have yet been found. Thus, Gy definitely results in hypophosphataemia and the possibility of allelism with Hyp is still open. However, the data so far do not explain why Gy/Y is more severely affected than Hyp/Y in terms of viability, growth, circling behaviour and sterility. Work is continuing. (Lyon and Jarvis) |
