| First Author | Phillips RJS | Year | 1977 |
| Journal | Mouse News Lett | Volume | 56 |
| Pages | 38 | Mgi Jnum | J:15082 |
| Mgi Id | MGI:63221 | Citation | Phillips RJS (1977) Description of the phenotypes of p-alleles (other than p) held at Harwell. Mouse News Lett 56:38 |
| abstractText | Full text of MNL contribution: 4. Description of the phenotypes of p-alleles (other than p) held at Harwell. Allele: pxpx +; Eyes at Birth: dark; Eyes at Weaning: dark; On agouti, black: Coat colour/Ear colour: only slightly lighter than wild-type; Behaviour*: normal; Probable origin: spontaneous (in C3H). Allele: pdpd; Eyes at Birth: light; Eyes at Weaning: dark; On agouti, black: Coat colour/Ear colour: similar in depth of colour to bb but less ÒorangeÓ; Behaviour*: normal; Probable origin: radiation induced. Allele: pbspbs; Eyes at Birth: dark; Eyes at Weaning: dark; On agouti, black: Coat colour/Ear colour: lighter than pdpd and in p rather than b-colour range. (Darker than pdn); Behaviour*: slightly jerker; Probable origin: radiation induced. Allele: pdnpdn +; Eyes at Birth: pink; Eyes at Weaning: dark; On agouti, black: Coat colour: slightly darker than pp; On agouti, black: Ear colour: light; Behaviour*: normal; Probable origin: EMS induced. Allele: p6Hp6H p25Hp25H; Eyes at Birth: pink; Eyes at Weaning: pink; On agouti, black: Coat colour/Ear colour: indistinguishable from pp; Behaviour*: MNL 57:18; Probable origin: radiation induced. Allele: pcppcp; Eyes at Birth: pink; Eyes at Weaning: pink; On agouti, black: Coat colour/Ear colour: indistinguishable from pp; Behaviour*: normal; Probable origin: radiation induced. Allele: pxppbspd; Eyes at Birth: dark; Eyes at Weaning: dark; On agouti, black: Coat colour: slightly lighter than pdpd; Ear colour: slightly darker than pdpd; Behaviour*: normal. Allele: pdp; Eyes at Birth: very light; Eyes at Weaning: dark; On agouti, black: Coat colour: slightly lighter than pxp andpbspd; Ear colour: light; Behaviour*: normal. Allele: pbsp; Eyes at Birth: dark; Eyes at Weaning: dark; On agouti, black: Coat colour/Ear colour: intermediate between pp and pbspbs; Behaviour*: normal. Allele: pbsp25H (or p6H); Eyes at Birth: dark; Eyes at Weaning: dark; On agouti, black: Coat colour/Ear colour: intermediate between pp and pbspbs; Behaviour*: slightly jerker. * The slightly jerker phenotypes tend to be smaller than normal and are generally male sterile, (1 out of 7 pbspbs males tested (by x to 3 females) had l litter of 2 mice and 1 out of 5 pbsp25H males tested had 1 litter of 4. 3 p6Hp6H, 3 p6Hp25H and 19 pbsp6H were sterile), the females are poor breeders. pbspbs abnormal sperm differ from those of p25Hp25H (Johnson and Hunt, MNL 47, 52). + Most die at birth from cleft palate but a few have lived, proved to resemble pp and to be fertile. + The alleles px (p-extra dark) and pdn (p-darkening) were obtained from Dr. B.M. Cattanach; though not recent mutations, neither has previously been recorded in the literature. In the combinations between 2 different alleles, dark on the whole appears to be dominant to light but there are some intermediate effects - for instance eye colour in pdp, ear colour in pd with p or pbs, coat colour in pbs with p. It may be that most or all of the effects are intermediate but that the differences are not observable by eye. px and pd fall into a darker, less p-looking category than pbs and pdn and this effect is phenotypically dominant. (Phillips) |
