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Protein Coding Gene : Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Primary Identifier  MGI:1353576 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  30955
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of Rac protein signal transduction; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within several processes, including cellular response to cAMP; negative regulation of fibroblast apoptotic process; and regulation of calcium ion transmembrane transport. Predicted to be located in cytosol and membrane. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in future spinal cord; hemolymphoid system; and thymus primordium. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
PHENOTYPE: Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration. [provided by MGI curators]
  • synonyms:
  • PI3K<gamma>,
  • PI(3)Kgamma,
  • RIKEN cDNA 5830428L06 gene,
  • 5830428L06Rik,
  • PI3Kgamma,
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma,
  • Pik3cg,
  • p110gamma,
  • MGI:1923289

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