| First Author | Højland A | Year | 2018 |
| Journal | Behav Brain Res | Volume | 348 |
| Pages | 90-100 | PubMed ID | 29660442 |
| Mgi Jnum | J:262637 | Mgi Id | MGI:6163226 |
| Doi | 10.1016/j.bbr.2018.04.017 | Citation | Hojland A, et al. (2018) Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner. Behav Brain Res 348:90-100 |
| abstractText | Beneficial effects of omega-3 fatty acid intake on cognition are under debate as some studies show beneficial effects while others show no effects of omega-3 supplementation. These inconsistencies may be a result of inter-individual response variations, potentially caused by gene and diet interactions. SorLA is a multifunctional receptor involved in ligand trafficking including lipoprotein lipase and amyloid precursor protein. Decreased SorLA levels have been correlated to Alzheimer's disease, and omega-3 fatty acid supplementation is known to increase SorLA expression in neuronal cell lines and mouse models. We therefore addressed potential correlations between Sorl1 and dietary omega-3 in SorLA deficient mice (Sorl1(-/-)) and controls exposed to diets supplemented with or deprived of omega-3 during their entire development and lifespan (lifelong) or solely from the time of weaning (post weaning). Observed diet-induced effects were only evident when exposed to lifelong omega-3 supplementation or deprivation as opposed to post weaning exposure only. Lifelong exposure to omega-3 supplementation resulted in impaired spatial learning in Sorl1(-/-) mice. The vitamin C antioxidant capacity in the brains of Sorl1(-/-) mice was reduced, but reduced glutathione and vitamin E levels were increased, leaving the overall antioxidant capacity of the brain inconclusive. No gross morphological differences of hippocampal neurons were found to account for the altered behavior. We found a significant adverse effect in cognitive performance by combining SorLA deficiency with lifelong exposure to omega-3. Our results stress the need for investigations of the underlying molecular mechanisms to clarify the precise circumstances under which omega-3 supplementation may be beneficial. |
